GLP-1 Pharmacogenomics Risk Calculator

Drug Medication Selection

Semaglutide GLP-1 receptor agonist

Ozempic · Wegovy · Compounded

Tirzepatide Dual GLP-1 + GIP receptor agonist

Mounjaro · Zepbound · Compounded

Current dose (mg/week)

Duration on drug (months)

Reason for use

DNA Genetic Data Upload

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Upload genotype file

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SUPPORTED FORMATS: VCF (.vcf) · 23andMe export (.txt/.tsv) · AncestryDNA · Generic tab-separated

Target SNPs for GLP-1 pharmacogenomics:
rs10305420 (GLP1R, Chr.6) — Efficacy variant p.Pro7Leu, effect allele T, P=2.9×10⁻¹⁰ | rs9357296 (GLP1R, Chr.6) — Nausea risk, effect allele G, OR=1.36 | rs11760106 (GLP1R, Chr.6) — Vomiting risk, effect allele T, OR=1.57 | rs1800437 (GIPR, Chr.19) — Tirzepatide vomiting p.Glu354Gln, risk allele C, OR=1.83

Manual genotype entry (or override file-detected values)

rs10305420

GLP1R

Efficacy — weight loss · p.Pro7Leu signal peptide

Effect allele: T | Ref: C
e.g. CC / CT / TT

rs9357296

GLP1R

Nausea risk (both drugs) · GLP1R locus

Risk allele: G | OR=1.36
e.g. CC / GC / GG

rs11760106

GLP1R

Vomiting risk (both drugs) · GLP1R locus

Risk allele: T | OR=1.57
e.g. CC / TC / TT

rs1800437

GIPR

Vomiting risk — tirzepatide only · p.Glu354Gln

Risk allele: C | Protective: G
e.g. GG / GC / CC

Demo Demographics

Biological sex

Age (years)

Ancestry / ethnicity

Anthro Anthropometrics

Height (cm)

Pre-treatment weight (kg)

Current weight (kg)

BMI summary

Enter height and weight above

Waist circumference (cm) Elevated: M >102 cm · F >88 cm

Hip circumference (cm) Used for WHR calculation

Glucose Glucose Metabolism

HbA1c (%) Normal <5.7 · Pre-DM 5.7–6.4 · DM ≥6.5

Fasting glucose (mg/dL) Normal <100 · Pre-DM 100–125 · DM ≥126

Fasting insulin (μIU/mL) HOMA-IR auto-calculated if entered

2-hr postprandial glucose (mg/dL) Normal <140 · IGT 140–199 · DM ≥200

C-peptide (ng/mL) Reflects endogenous insulin secretion

Fasting GLP-1 level (pmol/L) Optional — if assay available

Lipids Lipid Panel

Total cholesterol (mg/dL) Desirable <200

LDL-C (mg/dL) Optimal <100

HDL-C (mg/dL) Low: M <40 · F <50

Triglycerides (mg/dL) Normal <150 · High ≥500 (pancreatitis risk)

Renal/Hepatic Renal & Hepatic Function

eGFR (mL/min/1.73m²) Normal ≥60 · CKD3 30–59 · CKD4 15–29

Serum creatinine (mg/dL)

BUN / urea (mg/dL) Normal 7–20

Uric acid (mg/dL) Normal: M <7.0 · F <6.0

ALT (U/L) Normal: M <40 · F <35

AST (U/L) Normal: M <40 · F <32

GGT (U/L) Normal: M <55 · F <38

Albumin (g/dL) Normal 3.5–5.0

Total bilirubin (mg/dL) Normal 0.2–1.2

ALP (U/L) Normal 44–147

Cardio Cardiovascular & Inflammatory

Systolic BP (mmHg) Normal <120 · Stage 1 HTN 130–139

Diastolic BP (mmHg) Normal <80

Resting heart rate (bpm)

hs-CRP (mg/L) Low CV risk <1 · High >3

Ferritin (ng/mL) Normal: M 12–300 · F 12–150

Vitamin D (25-OH) (ng/mL) Deficiency <20 · Sufficient ≥30

TSH (mIU/L) Normal 0.4–4.0

Complete the inputs and click Calculate Risk Score to view results.