Reference: GWAS Catalog · MONDO:0004975
Method: Weighted Beta PRS
Build: GRCh38
01 · Input Data
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GWAS Catalog Reference
TSV file from GWAS Catalog
Fields: riskAllele, beta, pValue, mappedGenes…
Reference · TSV
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Patient Genome File
23andMe .txt format, or VCF (.vcf)
rsID + genotype per SNP
Input · 23andMe / VCF
Don't have files ready? Load synthetic demo data to explore the tool.
02 · Processing
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Parsing GWAS catalog — extracting SNPs, betas, genes…
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Parsing genome file — detecting format (23andMe / VCF)…
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Matching SNPs — finding common rsIDs…
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Calculating weighted PRS — dosage × beta…
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Classifying risk — normalising score…
03 · Risk Assessment
0 100
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PRS SCORE (0–100)
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GWAS SNPs Loaded
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Matched SNPs
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Risk-contributing
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Protective
Raw PRS (β-weighted)
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Coverage of Reference Panel
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Clinical Interpretation
Matched SNP Detail

SNPs Found in Sample · 0 matches

rsID Gene(s) Risk Allele Genotype Dosage Contribution p-value Direction
Gene-Level Breakdown
⚠️
Research & Educational Use Only. This tool calculates a Polygenic Risk Score based on GWAS summary statistics. PRS does not diagnose Alzheimer's disease or predict individual outcomes. Genetic risk is one factor among many; lifestyle, environment, and clinical history are equally important. Always consult a qualified clinical geneticist or neurologist for medical interpretation. This tool is not a substitute for professional medical advice.