Varun Sharma, Ph.D., MRSB

Scientist

I am not befooled or baffled from the research in sciences as none of it is final..........by V.K.T

PUBLICATION

Research Papers:

  1. Husami SF, Kaur T, Gupta L, Rastogi G, Singh L, Meena P, Sharma I, Singh H, Sharma V Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals. Sci Rep. 2025 Jan 2;15(1):506. doi: 10.1038/s41598-024-84160-2. (Corresponding Author)
  2. SSandhu S, Kumar S, Singh P, Singh BP, Jurel SK, Lal N, Mohit, Sharma V, Rai N, Chand P. Metagenomic profiling of plaque microbiota in Indian subjects: identified hidden ecological tapestry. Curr Genet. 2025 Jan 24;71(1):3. doi: 10.1007/s00294-024-01306-5. (Corresponding Author)
  3. Kumar, H., Singh, R., Dhanjal, D. S., Chopra, C., Cruz-Martins, N., Nasrallah, G. K., Sharma V (2023). Impact of Phytoconstituents on Oral Health Practices: A Post COVID-19 Observation. Food Science and Human Wellness. doi: 10.26599/FSHW.2022.9250197.(Corresponding Author)
  4. Sandhu S, Sharma V, Kumar S, Rai N, Chand P. Quantifying variations associated with dental caries reveals disparity in effect allele frequencies across diverse populations. BMC Genom Data. 2024 Jun 3;25(1):50. doi: 10.1186/s12863-024-01215-z.(Shared First Author)
  5. Mehra R, Patra V, Dhillan R, Sharma A, Kashyap S, Rastogi G, Gupta L, Singh R, Chopra C, Sharma V. Replication study identified EFEMP1 association with varicose vein predisposition among Indians. Eur J Med Res. 2024 Apr 12;29(1):232. doi: 10.1186/s40001-024-01786-8. (Corresponding Author)
  6. Naik S, Sudan J, Urwat U, Pakhtoon MM, Bhat B, Sharma V , Sofi PA, Shikari AB, Bhat BA, Sofi NR, Prasad PVV, Zargar SM. Genome-wide SNP discovery and genotyping delineates potential QTLs underlying major yield-attributing traits in buckwheat. Plant Genome. 2024 Mar;17(1):e20427. doi: 10.1002/tpg2.20427. Epub 2024 Jan 18.
  7. Singh H, Chopra C, Singh H, Malgotra V, Wani A.K, Dhanjal D.S, Sharma I, Eugenie Nepovimova, Alomar S, Reena Singh, Sharma V, Kuca K, Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies, Journal of Functional Foods,112, 2024, doi.org/10.1016/j.jff.2023.105915. (Corresponding Author)
  8. KG Bhat , RKJ Pillai, Lodhi H, Guleria VS, Abbot AK, Gupta L, Rastogi G, Sharma A, Mohammed Z, Sharma V. Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians. J Gene Med. 2023 Nov 20:e3634. doi: 10.1002/jgm.3634. (Corresponding Author)
  9. Dhanjal DS, Singh R, Sharma V, Nepovimova E, Adam V, Kuca K, Chopra C. Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine. Curr Med Chem. 2024;31(13):1646-1690. doi: 10.2174/0929867330666230503144619.
  10. Bhardwaj S, Mehra P, Dhanjal DS, Sharma P, Sharma V, Singh R, Nepovimova E, Chopra C, Kuča K. Antibiotics and Antibiotic Resistance- Flipsides of the Same Coin. Curr Pharm Des. 2022;28(28):2312-2329. doi: 10.2174/1381612828666220608120238.
  11. Spolia A, Angural A, Sharma V, Shipra, Razdan S, Dhar MK, Mahajan A, Verma V, Pandita KK, Sharma S, Rai E. Cost-effective Whole Exome Sequencing discovers pathogenic variant causing Neurofibromatosis type 1 in a family from Jammu and Kashmir, India. Sci Rep. 2023 May 15;13(1):7852. doi: 10.1038/s41598-023-34941-y.
  12. Dhanjal DS, Singh R, Sharma V,, Nepovimova E, Adam V, Kuca K, Chopra C. Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine. Curr Med Chem. 2023 May 3. doi: 10.2174/0929867330666230503144619.
  13. Singh PP, Rai SK, Chaubey G; Serosurveillance Consortium BHU. Estimation of real COVID-19 cases in India during the first wave. IJID Reg. 2023 Mar;6:80-83. doi: 10.1016/j.ijregi.2023.01.008. (Part of BHU Serosurveillance consortium and data generated for the Lucknow District of Uttar Pradesh, India).
  14. Bhat KG, Guleria VS, J RK, Rastogi G, Sharma V, Sharma A. Preliminary genome wide screening identifies new variants associated with coronary artery disease in Indian population. Am J Transl Res. 2022 Jul 15;14(7):5124-5131. (Corresponding Author).
  15. Mohit, Sharma I, Sharma V, Kumar S, Rastogi G, Dutt P, Shrivastava A, Rai N, Chand P. Empirical assessment of allele frequencies of genome wide association study variants associated with obstructive sleep apnea. Am J Transl Res. 2022 May 15;14(5):3464-3471. (Shared First Author).
  16. Sharma V, Sharma I, Gupta L, Rastogi G and Sharma A (2022). "Polygenic Risk Score Comparative Analyses Reveals Risk Disparity of Genetic Predisposition to Chronic Kidney Disease- A Multi Ancestry Approach." medRxiv: 2022.2007.2005.22277245. (Preprint).
  17. Asrar R., Zainab A M, Sharma V, Gupta L, Hoda, A., . . . Amir, H. (2022). Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models. bioRxiv, 2022.2011.2006.515327. doi: 10.1101/2022.11.06.515327 ,(Preprint).
  18. Bhardwaj S, Mehra P, Dhanjal DS, Sharma P, Sharma V, Singh R, Nepovimova E, Chopra C, Kuča K. Antibiotics and Antibiotic Resistance- Flipsides of the Same Coin. Curr Pharm Des. 2022;28(28):2312-2329. doi: 10.2174/1381612828666220608120238.
  19. Sharma V, Sharma A, Gupta L, RE: Better to Provide Vaccine Dose to Immune Compromised Individuals than Booster Dose to Vaccinated Individuals (reply to Cohn, Barbara A et al. “SARS-CoV-2 vaccine protection and deaths among US veterans during 2021.” Science (New York, N.Y.) vol. 375, 6578 (2022): 331-336.
  20. Singh H, Shipra, Sharma V, Sharma I, Sharma A, Modeel S, Gupta N, Gupta G, Pandita AK, Butt MF, Sharma R, Pandita S, Singh V, Rai E, Ikegawa S, Sharma S. The first study of epidemiology of adolescent idiopathic scoliosis shows lower prevalence in females of Jammu and Kashmir, India. Am J Transl Res. 2022 Feb 15;14(2):1100-1106. PMID: 35273713
  21. Sharma M, Chopra C, Mehta M, Sharma V, Mallubhotla S, Sistla S, Sistla JC, Bhushan I. An Insight into Vaginal Microbiome Techniques. Life (Basel). 2021 Nov 13;11(11):1229. doi: 10.3390/life11111229. (Shared First Author)
  22. BHU Serosurvillance Consortium (2021). The association of ABO blood group with the asymptomatic COVID-19 cases in India. Transfusion and apheresis science: official journal of the World Apheresis Association: official journal of the European Society for Haemapheresis, 60(6), 103224 (Part of BHU Serosurveillance consortium and data generated for the Lucknow District of Uttar Pradesh, India)
  23. BHU Serosurvillance Consortium (2021). RE: Why there is Second Wave in India? eLetter, Science (reply to Buss et.al., "Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic".Science371,288-292(2021).DOI:10.1126/science.abe9728)
  24. Fareed M, Sharma V, Singh I, Rehman SU, Singh G, Afzal M. Whole-Exome Sequencing Reveals a Rare Variant of OTOF Gene Causing Congenital Non-syndromic Hearing Loss Among Large Muslim Families Favoring Consanguinity. Front Genet. 2021 May 25;12:641925. doi: 10.3389/fgene.
  25. Shah R,Verma S, Bhat A , Bhat Gh R, Sharma V, Sharma I,Singh H, Kaul S, Rai E, Sharma S, (2021). Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India, Biocell. 45 (3) 665–670.
  26. Bhushan I, Sharma M, Mehta M, Badyal S, Sharma V, Sharma I, Singh H, Sistla S. Bioactive compounds and probiotics–a ray of hope in COVID-19 management. Food Science and Human Wellness. 2021 Mar;10(2):131–40. doi: 10.1016/j.fshw.2021.02.001.
  27. Singh G, Yellapu S, Sandhu HS, Sharma I, Sharma V, Bhanwer AJS. Genetic characterisation of the North-West Indian populations: analysis of mitochondrial DNA control region variations. Ann Hum Biol. 2021 Mar;48(2):166-172. doi: 10.1080/03014460.2021.1879933.
  28. Verma S, Sharma I, Sharma V, Bhat A, Shah R, Bhat GR, Sharma B, Bakshi D, Nagpal A, Wakhloo A, Bhat A, Kumar R. MassArray analysis of genomic susceptibility variants in ovarian cancer. Sci Rep. 2020 Dec 3;10(1):21101. doi: 10.1038/s41598-020-76491-7.
  29. Bakshi D, Nagpal A, Sharma V, Sharma I, Shah R, Sharma B, Bhat A, Verma S, Bhat GR, Abrol D, Sharma R, Vaishnavi S, Kumar R. MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population. BMC Cancer. 2020 Sep 7;20(1):861. doi: 10.1186/s12885-020-07361-8.
  30. Shah R, Sharma V, Bhat A, Singh H, Sharma I, Verma S, Bhat GR, Sharma B, Bakshi D, Kumar R, Dar NA. MassARRAY analysis of twelve cancer related SNPs in esophageal squamous cell carcinoma in J&K, India. BMC Cancer. 2020 Jun 1;20(1):497. doi: 10.1186/s12885-020-06991-2. PMID: 32487238; PMCID: PMC7268327.
  31. Sethi I, Sharma V, Sharma I, Singh G, Bhat GR, Bhanwer AJS, Sharma S, Rai E. Telomere Maintenance Genes are associated with Type 2 Diabetes Susceptibility in Northwest Indian Population Group. Sci Rep. 2020 Apr 15;10(1):6444. doi: 10.1038/s41598-020-63510-w. PMID: 32296102; PMCID: PMC7160122.
  32. Lalrohlui F, Sharma V,Sharma I,Singh H, Kour G, Sharma S, Yuman, Zohmingthanga J, Vanlalhruaii, & Rai E, Singh, Singh V & Nachimuthu Sharma S,. MACF1 gene variant rs2296172 is associated with T2D susceptibility in Mizo population from Northeast India. Int J Diabetes Dev Ctries 40, 223–226 (2020). https://doi.org/10.1007/s13410-019-00788-1 (First Shared Author).
  33. Lalrohlui, F, Sharma V, Sharma, I, Rai, E, Zohmingthanga, J., Hruaii, V., . . . Senthil Kumar, N. (2020). Genotyping of T2D susceptible genes in a high risk North-East Indian population. Obesity Medicine, 17, 100162. doi: https://doi.org/10.1016/j.obmed.2019.100162. (First Shared Author).
  34. Shah R, Sharma V, Singh H, Sharma I, Bhat GA, Shah IA, Iqbal B, Rafiq R, Nissa N, Muzaffar M, Rasool MT, Lone GN, Kaul S, Lone MM, Rai E, Dar NA, Sharma S. LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir. J Cancer Res Ther. 2020 Dec;16(Supplement):S156-S159. doi: 10.4103/jcrt.JCRT_613_19.
  35. Verma S, Bakshi D, Sharma V, Sharma I, Shah R, Bhat A, Bhat GR, Sharma B, Wakhloo A, Kaul S, Heer V, Bhat A, Abrol D, Verma V, Kumar R. Genetic variants of DNAH11 and LRFN2 genes and their association with ovarian and breast cancer. Int J Gynaecol Obstet. 2020 Jan;148(1):118-122. doi: 10.1002/ijgo.12997.
  36. Verma S, Sharma V, Nagpal A, Bhat A, Bhat GR, Shah R, Wakhloo A, Suri J, Abrol D, Kaul S, Bhat A, Verma V, Kumar R. DNA base excision repair genes variants rs25487 (X-ray repair cross-complementing 1) and rs1052133 (human 8-oxoguanine glycosylase 1) with susceptibility to ovarian cancer in the population of the Jammu region, India. J Cancer Res Ther. 2019 Oct-Dec;15(6):1270-1275. doi: 10.4103/jcrt.JCRT_65_18.
  37. Sudan J, Singh R, Sharma S, Salgotra RK, Sharma V, Singh G, Sharma I, Sharma S, Gupta SK, Zargar SM. ddRAD sequencing-based identification of inter-genepool SNPs and association analysis in Brassica juncea. BMC Plant Biol. 2019 Dec 30;19(1):594. doi: 10.1186/s12870-019-2188-x.
  38. Rasool Bhat GH, Bhat A, Verma S, Sethi I, Shah R, Sharma V, Minerva S, Bakshi D, Sharma B, Koul S, Abrol D, Bhat A, Kumar R. Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population. J Genet. 2019 Jun;98(2):59.
  39. Bhat GR, Bhat A, Verma S, Sethi I, Shah R, Sharma V, Dar KA, Abrol D, Kaneez S, Kaul S, Ganju R, Kumar R. Association of newly identified genetic variant rs2853677 of TERT with non-small cell lung cancer and leukemia in population of Jammu and Kashmir, India. BMC Cancer. 2019 May 24;19(1):493. doi: 10.1186/s12885-019-5685-2. PMID: 31126249; PMCID: PMC6533689.
  40. Bhat A, Shah R, Bhat GR, Verma S, Sharma V, Sharma I, Pandita M, Bakshi D, Sharma B, Suri J, Kumar R. Association of ARID5B and IKZF1 Variants with Leukemia from Northern India. Genet Test Mol Biomarkers. 2019 Mar;23(3):176-179. doi: 10.1089/gtmb.2018.0283.
  41. Angural A, Sharma I, Pandoh P, Sharma V, Spolia A, Rai E, Singh V, Razdan S, Pandita KK, Sharma S. A case report on a novel MT-ATP6 gene variation in atypical mitochondrial Leigh syndrome associated with bilateral basal ganglia calcifications. Mitochondrion. 2019 May;46:209-213. doi: 10.1016/j.mito.2018.06.005.
  42. Sharma I, Sharma V, Khan A, Kumar P, Rai E, Bamezai RNK, Vilar M, Sharma S. Ancient Human Migrations to and through Jammu Kashmir- India were not of Males Exclusively. Sci Rep. 2018 Jan 16;8(1):851. doi: 10.1038/s41598-017-18893-8. (Shared First Author)
  43. Sharma V, Sethi, I., Sharma, I. et al. Replication of MACF1 gene variant rs2296172 with type 2 diabetes susceptibility in the Bania population group of Punjab, India. Int J Diabetes Dev Ctries 38, 387–390 (2018). https://doi.org/10.1007/s13410-017-0598-6.
  44. Sahakyan H, Hooshiar Kashani B, Tamang R, Kushniarevich A, Francis A, Costa MD, Pathak AK, Khachatryan Z, Sharma I, van Oven M, Parik J, Hovhannisyan H, Metspalu E, Pennarun E, Karmin M, Tamm E, Tambets K, Bahmanimehr A, Reisberg T, Reidla M, Achilli A, Olivieri A, Gandini F, Perego UA, Al-Zahery N, Houshmand M, Sanati MH, Soares P, Rai E, Šarac J, Šarić T, Sharma V, Pereira L, Fernandes V, Černý V, Farjadian S, Singh DP, Azakli H, Üstek D, Ekomasova Trofimova N, Kutuev I, Litvinov S, Bermisheva M, Khusnutdinova EK, Rai N, Singh M, Singh VK, Reddy AG, Tolk HV, Cvjetan S, Lauc LB, Rudan P, Michalodimitrakis EN, Anagnou NP, Pappa KI, Golubenko MV, Orekhov V, Borinskaya SA, Kaldma K, Schauer MA, Simionescu M, Gusar V, Grechanina E, Govindaraj P, Voevoda M, Damba L, Sharma S, Singh L, Semino O, Behar DM, Yepiskoposyan L, Richards MB, Metspalu M, Kivisild T, Thangaraj K, Endicott P, Chaubey G, Torroni A, Villems R. Origin and spread of human mitochondrial DNA haplogroup U7. Sci Rep. 2017 Apr 7;7:46044. doi: 10.1038/srep46044.
  45. Sharma V, Sharma I, Sethi I, Mahajan A, Singh G, Angural A, Bhanwer AJS, Dhar MK, Singh V, Rai E, Sharma S. Replication of newly identified type 2 diabetes susceptible loci in Northwest Indian population. Diabetes Res Clin Pract. 2017 Apr;126:160-163. doi: 10.1016/j.diabres.2017.02.013.
  46. Sharma V, Sharma I, Singh VP, Verma S, Pandita A, Singh V, Rai E, Sharma S. mtDNA G10398A variation provides risk to type 2 diabetes in population group from the Jammu region of India. Meta Gene. 2014 Apr 13;2:269-73. doi: 10.1016/j.mgene.2014.02.003.

    47. Book Chapters:

    1. I. Sharma, J. Sharma, H. Singh, V. Sharma, Biomarkers for Cancer Therapy, Modern Cancer Therapies and Traditional Medicine: An Integrative Approach to Combat Cancers, Bentham Science, ISSN: 9789814998673, Chapter 3, pp 47-55, 2021 (Corresponding Author)
    2. H. Singh, I. Sharma,V. Sharma, Clinical Tools in Clinical Oncology, Modern Cancer Therapies and Traditional Medicine: An Integrative Approach to Combat Cancers, Bentham Science, ISSN: 9789814998673, Chapter 9, pp 188-199, 2021(Corresponding Author)
    3. J. Sharma, S. Sharma, I. Sharma, C. Chopra, V. Sharma, The coming together of Sciences: Metagenomics for Microbial Biochemistry. Metagenomics: Techniques, Applications, Challenges and Opportunities, Springer Nature ISBN 978-981-15-6528-1; Chapter 2, pp 23-33, 2020(Corresponding Author)
    4. H. Singh, I. Sharma, V. Sharma, Epidemiological Perspectives of Human Health through Metagenomic Research. Springer Nature Singapore, ISBN 978-981-15-6528-1; Chapter 9, pp 147-156, 2020 (Corresponding Author)
    5. J. Sharma, V. Sharma, I. Sharma, The Skin Metagenomes: Insights into Involvement of Microbes in Diseases, Springer Nature, ISBN 978-981-15- 6528-1; Chapter 12, pp 189-198, 2020.

    Articles in Proceedings:

    1. V. Sharma, I. Sethi, I. Sharma, G. Singh, , A. Mahajan, A. Angural, A.J.S. Bhanwer, M K. Dhar, K.K. Pandita, V. Singh, E. Rai, S. Sharma (2017). MACF1 Gene variant rs2296172 is Associated with T2D Susceptibility in Bania Population group of Punjab-India. Canadian Journal of Biotechnology, (Special Issue), 79.
    2. I. Sharma, V. Sharma, P. Kumar, E. Rai, M. Vilar, S. Sharma. (2017), Y Chromosome Haplogroup Distribution in Different Ethnic Groups of Jammu and Kashmir. Canadian Journal of Biotechnology, (Special Issue), 168.
    3. V. Sharma, I. Sharma, E. Rai, V. Singh, K.K. Pandita, S. Sharma. (2014). Amyotrophic Lateral Sclerosis (ALS) – An Overview. Indian Journal of Human Genetics, Vol 20(Supplement 1), S108.
    4. Sharma, I., V. Sharma, E. Rai, V. Singh, S. Sharma. (2014). Genetic Diversity in Reasi and Udhampur District of Jammu and Kashmir, India. Indian Journal of Human Genetics, Vol 20(Supplement 1), S104.