AD Therapeutic Target Predictor

Alzheimer's Disease Therapeutic Target Discovery

Upload all six datasets, configure your ML models, and run the full analysis pipeline to identify oxidative stress and glucose metabolism genes as potential drug targets in AD.

🔬

Ready to analyse

Upload your 6 datasets in the sidebar (GEO expression, 4 GWAS files, OpenTargets), configure thresholds, select ML models, then click Run Analysis.

7 ML Models

WMSS · ZSA · Borda · EC · LogReg · PU-Boot · Ensemble

22 Features

GEO + 4 GWAS + OpenTargets druggability

Full export

CSV download of all predictions and scores

Score Distribution (Ensemble)

Top 20 Targets by Ensemble Score

Evidence Source Overlap

DEG Expression Profile

#	Gene	log2FC	padj	Sources	OT Score	WMSS	ZSA	Borda	Evidence	LogReg	PU-Boot	Ensemble	Druggable

ℹ Candidates are ranked by ensemble score. Badges indicate the evidence streams each gene appears in. Druggable = hasPocket or hasSmallMoleculeBinder in OpenTargets.

ℹ Hover over points to see gene details. Teal = oxidative stress GWAS. Blue = glucose metabolism GWAS. Purple = AD GWAS. Grey = other DEGs.

Alzheimer's Disease Therapeutic Target Discovery

Ready to analyse

Score Distribution (Ensemble)

Top 20 Targets by Ensemble Score

Evidence Source Overlap

DEG Expression Profile

Feature Importance (across active models)

WMSS Weight Contribution

Logistic Regression Coefficients

Model Score Correlation (top 200)

Rank Agreement — Top 50 Targets

Per-model performance summary